The main purpose of this research is to formulate best policy measure to minimize the expected problems when adopting and implementing GHS system in Korea and to draft the revision proposal for Industrial Safety and Health Act taking into account of unique domestic situation. The research method is to conduct a survey for 2 month period from early April to late May in 2006 to 830 randomly selected chemical manufacturing, importing and exporting, and consumption companies out of all the companies surveyed by the Ministry of Labor under 2004 Work Environment Status National Survey. A total of 610 survey was collected and analyzed. The results of this thesis is summarized as follows ; First, based on the survey analysis it is vital to conduct a national PR using pamphlet, internet, and daily newspaper and to provide technical assistance such as training expert and publishing GHS manual by expert organization such as Korea Occupational Safety and Health Agency (KOSHA) for early settlement of GHS in Korea. Second, it is also needed to give a grace period of 1 to 2 years to minimize the dramatic impact for industry, to encourage the establishment of the GHS team utilizing safety managers within companies, and to develop and distribute the standard GHS software by government. Third, taking into account of difficult situation of small companies, KOSHA needs to provide a full technical and financial support for companies with less than 100 employees and especially for chemical manufacturing companies. Fourth, it is also needed to operate an Interministrial GHS Committee (IGC) involving 7 related ministries for smooth GHS implementation and to develop an infra by sharing responsibilities among related ministries and establishing internationally recognized organization for hazard classification, labelling, and MSDS.