Exposure to the indoor air pollutants could be associated with the risk of developing atopic dermatitis, including allergic symptoms and exacerbations. A total of Fifty homes who had a past or current symptoms of atopic dermatitis were enrolled in the study. To rate the levels of environmental factor, we measured concentrations of PM2.5, PM10, Heavy metals XRF (X-Ray Fluorescene), Bacteria (CFU/m3), mold (CFU/m3) in dust of the children’s houses. The prevalence of atopic dermatitis in children is increasing especially in Urban areas. Exposure to levels of indoor environmental factor and air pollutants has been related to atopic dermatitis development. The house dust were higher for the results of atopy, asthma patients analyzed fungi and bacteria, resulting XRF measurements Cr (chromium), As (arsenic), Br (bromine), Cd (cadmium), Hg (mercury), Pb (lead) etc. this has a significant relationship. Recent studies have shown that indoor air pollutants control is beneficial in reducing atopic dermatitis prevalence and development. Urban areas children are exposed to kinds of indoor environmental factor and air pollutants that may lead to atopic dermatitis development. Keywords : Atopic dermatitis, Fungi, House dust mites, Indoor air