In architecture, constitutions of space are subjected to the structural material and interior finishing material. Interior environment can exert a great effect on people by means of space constitution. In this study the constitution of space was set to consider five materials: control, wood, steel, wire mesh, and concrete structural material. In this study, experiments with mice, were carried out on condition of each living environment with different living environment using control, wood, steel, wire mesh and concrete structural material. The experiments with mice were made by five-month-old mice(BALB/C) with about 15 grams weight. In order to evaluate the adaptability of the target mice, such variables as body weight, food consumption, and water consumption were monitored against living environment for normal BALB/C mice during the same period. The weight, total foods, and total water consumption were measured under the living environments for 55 days with 2~3 days intervals. To test five different living environments, i.e., control, wood, steel, wire mesh and concrete, 5 mice were allocated for each group. According to the results of this study, the case of wood living environment resulted in a gain in weight with statistical significance. The other side of steel, wire mesh and concrete showed a slight decrease for weight. The weight variation of the experimental mice was assumed under five different living environments that resulted from the stabilized environmental conditions such as the wood living environment. Keywords：Living environment, Structural material, Constitutions of space, Weight variation