Numerical simulation using computational fluid dynamics (CFD) was performed to calculate the predicted mean vote (PMV) based on velocity and temperature profiles of air in a partitioned office building. The office building (W:14.65 m, D:7.57 m, and H:2.63 m) was divided by partitions of 1.5 m height and shared by 7 office workers. Each person uses a personal computer and printer on a desk. One stand-type air conditioner was installed in the corner of the room and operated at the variable flow rate of 35 ㎥/min. In the case study, we assumed that the initial temperature of the room was 303 K and it was cooled down by operating air-conditioner. The outside temperature was fixed at 303K and the heat flux through the windows was included in the calculation. Heat sources of personal computers, human bodies, fluorescent lamps, and refrigerator were considered. The temperature and PMV values were also calculated to asses the thermal comfort of each person by operating time of air conditioner. It was found that the thermal comfort could be improved by changing the angle of diffuser grill of air conditioner. Keywords：CFD, PMV, Thermal comfort, Partitions